Factors affecting the natural decay of hepatitis b surface antigen in children with chronic hepatitis b virus infection during long-term follow-up

Yu Chun Chiu; Shu Fen Liao; Jia Feng Wu; Chun Yin Lin; Wen Chung Lee; Huey Ling Chen; Yen Hsuan Ni; Hong Yuan Hsu; Mei Hwei Chang

doi:10.1016/j.jpeds.2014.06.059

Factors affecting the natural decay of hepatitis b surface antigen in children with chronic hepatitis b virus infection during long-term follow-up

Yu Chun Chiu
, Shu Fen Liao
, Jia Feng Wu
, Chun Yin Lin
, Wen Chung Lee
, Huey Ling Chen
, Yen Hsuan Ni
, Hong Yuan Hsu
, Mei Hwei Chang

研究成果: 雜誌貢獻 › 文章 › 同行評審

27 引文斯高帕斯（Scopus）

摘要

Objective To investigate the factors predicting spontaneous clearance of hepatitis B surface antigen (HBsAg) in a long-term, prospectively followed cohort from childhood into adult life.

Study design Children with chronic hepatitis B virus (HBV) infection without treatment were followed longitudinally every 6 months. At each visit, liver profiles and HBV markers were assessed. Hepatitis B vaccination history and the maternal HBV markers also were studied.

Results A total of 349 children (205 male) were followed for 20.6 ± 4.4 years with initial ages of 8.4 ± 3.9 years; 42 (12.0%) cleared HBsAg spontaneously. The HBsAg titers decayed with age, with an average annual clearance rate of 0.58%. Children had a lower annual HBsAg decay rate if their mothers are HBsAg carriers (P
Conclusions During long-term follow-up, spontaneous HBsAg clearance is most likely to occur in a patient born to a non-HBsAg-carrier mother, is a hepatitis B e antigen-seroconverter, and had an initial HBsAg level ≥1000 IU/mL.

原文	英語
頁（從 - 到）	767-772.e1
期刊	Journal of Pediatrics
卷	165
發行號	4
DOIs	https://doi.org/10.1016/j.jpeds.2014.06.059
出版狀態	已發佈 - 10月 2014
對外發佈	是

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

ASJC Scopus subject areas

兒科、圍產兒和兒童健康

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10.1016/j.jpeds.2014.06.059

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@article{5e0a9f18547a4f3cafa7e8c0dd3702aa,

title = "Factors affecting the natural decay of hepatitis b surface antigen in children with chronic hepatitis b virus infection during long-term follow-up",

abstract = "Objective To investigate the factors predicting spontaneous clearance of hepatitis B surface antigen (HBsAg) in a long-term, prospectively followed cohort from childhood into adult life.Study design Children with chronic hepatitis B virus (HBV) infection without treatment were followed longitudinally every 6 months. At each visit, liver profiles and HBV markers were assessed. Hepatitis B vaccination history and the maternal HBV markers also were studied.Results A total of 349 children (205 male) were followed for 20.6 ± 4.4 years with initial ages of 8.4 ± 3.9 years; 42 (12.0\%) cleared HBsAg spontaneously. The HBsAg titers decayed with age, with an average annual clearance rate of 0.58\%. Children had a lower annual HBsAg decay rate if their mothers are HBsAg carriers (P <.001). Hepatitis B e antigen-seroconversion is a favorable predictor for spontaneous HBsAg clearance (P =.04). Those with HBsAg titer ≥1000 IU/mL at enrollment during childhood have a higher rate of HBsAg clearance (hazard ratio = 5.23; P <.001). Using HBsAg titer ≥1000 IU/mL to predict HBsAg clearance, the sensitivity is 38.1\%, specificity is 90.6\%, positive predictive value is 35.6\%, and negative predictive value is 91.4\%.Conclusions During long-term follow-up, spontaneous HBsAg clearance is most likely to occur in a patient born to a non-HBsAg-carrier mother, is a hepatitis B e antigen-seroconverter, and had an initial HBsAg level ≥1000 IU/mL.",

author = "Chiu, \{Yu Chun\} and Liao, \{Shu Fen\} and Wu, \{Jia Feng\} and Lin, \{Chun Yin\} and Lee, \{Wen Chung\} and Chen, \{Huey Ling\} and Ni, \{Yen Hsuan\} and Hsu, \{Hong Yuan\} and Chang, \{Mei Hwei\}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = oct,

doi = "10.1016/j.jpeds.2014.06.059",

language = "English",

volume = "165",

pages = "767--772.e1",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Factors affecting the natural decay of hepatitis b surface antigen in children with chronic hepatitis b virus infection during long-term follow-up

AU - Chiu, Yu Chun

AU - Liao, Shu Fen

AU - Wu, Jia Feng

AU - Lin, Chun Yin

AU - Lee, Wen Chung

AU - Chen, Huey Ling

AU - Ni, Yen Hsuan

AU - Hsu, Hong Yuan

AU - Chang, Mei Hwei

PY - 2014/10

Y1 - 2014/10

N2 - Objective To investigate the factors predicting spontaneous clearance of hepatitis B surface antigen (HBsAg) in a long-term, prospectively followed cohort from childhood into adult life.Study design Children with chronic hepatitis B virus (HBV) infection without treatment were followed longitudinally every 6 months. At each visit, liver profiles and HBV markers were assessed. Hepatitis B vaccination history and the maternal HBV markers also were studied.Results A total of 349 children (205 male) were followed for 20.6 ± 4.4 years with initial ages of 8.4 ± 3.9 years; 42 (12.0%) cleared HBsAg spontaneously. The HBsAg titers decayed with age, with an average annual clearance rate of 0.58%. Children had a lower annual HBsAg decay rate if their mothers are HBsAg carriers (P <.001). Hepatitis B e antigen-seroconversion is a favorable predictor for spontaneous HBsAg clearance (P =.04). Those with HBsAg titer ≥1000 IU/mL at enrollment during childhood have a higher rate of HBsAg clearance (hazard ratio = 5.23; P <.001). Using HBsAg titer ≥1000 IU/mL to predict HBsAg clearance, the sensitivity is 38.1%, specificity is 90.6%, positive predictive value is 35.6%, and negative predictive value is 91.4%.Conclusions During long-term follow-up, spontaneous HBsAg clearance is most likely to occur in a patient born to a non-HBsAg-carrier mother, is a hepatitis B e antigen-seroconverter, and had an initial HBsAg level ≥1000 IU/mL.

AB - Objective To investigate the factors predicting spontaneous clearance of hepatitis B surface antigen (HBsAg) in a long-term, prospectively followed cohort from childhood into adult life.Study design Children with chronic hepatitis B virus (HBV) infection without treatment were followed longitudinally every 6 months. At each visit, liver profiles and HBV markers were assessed. Hepatitis B vaccination history and the maternal HBV markers also were studied.Results A total of 349 children (205 male) were followed for 20.6 ± 4.4 years with initial ages of 8.4 ± 3.9 years; 42 (12.0%) cleared HBsAg spontaneously. The HBsAg titers decayed with age, with an average annual clearance rate of 0.58%. Children had a lower annual HBsAg decay rate if their mothers are HBsAg carriers (P <.001). Hepatitis B e antigen-seroconversion is a favorable predictor for spontaneous HBsAg clearance (P =.04). Those with HBsAg titer ≥1000 IU/mL at enrollment during childhood have a higher rate of HBsAg clearance (hazard ratio = 5.23; P <.001). Using HBsAg titer ≥1000 IU/mL to predict HBsAg clearance, the sensitivity is 38.1%, specificity is 90.6%, positive predictive value is 35.6%, and negative predictive value is 91.4%.Conclusions During long-term follow-up, spontaneous HBsAg clearance is most likely to occur in a patient born to a non-HBsAg-carrier mother, is a hepatitis B e antigen-seroconverter, and had an initial HBsAg level ≥1000 IU/mL.

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U2 - 10.1016/j.jpeds.2014.06.059

DO - 10.1016/j.jpeds.2014.06.059

M3 - Article

C2 - 25112693

AN - SCOPUS:84908250507

SN - 0022-3476

VL - 165

SP - 767-772.e1

JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 4

ER -

Factors affecting the natural decay of hepatitis b surface antigen in children with chronic hepatitis b virus infection during long-term follow-up

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