Factors affecting recurrence in node-negative advanced gastric cancer

Kuo Hung Huang, Jen Hao Chen, Chew Wun Wu, Su Shun Lo, Mao Chih Hsieh, Anna F.Y. Li, Win Yiu Lui

研究成果: 雜誌貢獻文章同行評審

51 引文 斯高帕斯(Scopus)


Background and Aim: Prognostic factors of lymph node-negative gastric adenocarcinoma after curative resection have been discussed. Recurrent pattern of advanced lymph node-negative gastric cancer after curative resection has rarely been described. Methods: Recurrent sites and correlated clinicopathological factors of 372 patients with lymph node-negative advanced gastric adenocarcinoma that underwent R0 resection from 1988 to 2005 were analyzed. Results: Recurrence was noted in 51 (13.7%) patients. Recurrent rates according to site of recurrence were 26 peritoneal seeding (51.0%), 26 locoregional (51.0%), 17 hematogenous (33.3%), and 4 lymph node metastasis (7.8%). Clinicopathological factors to predict peritoneal seeding were serosal exposure, lymphovascular invasion, Lauren's diffuse type differentiation and scirrhous stromal reaction. Serosal exposure, tumor size, microscopic infiltrating growth type predicts locoregional recurrence. Tumor had only lymphovascular invasion predict hematogenous spreading. Conclusion: Node-negative advanced gastric cancer has more peritoneal seeding and locoregional recurrence. Aggressive cell behavior predicted the route of tumor cell spreading.

頁(從 - 到)1522-1526
期刊Journal of Gastroenterology and Hepatology (Australia)
出版狀態已發佈 - 9月 2009

ASJC Scopus subject areas

  • 肝病
  • 消化內科


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