Fabrication of ordered metallic glass nanotube arrays for label-free biosensing with diffractive reflectance

Wei Ting Chen, Shao Sian Li, Jinn P. Chu, Kuei Chih Feng, Jem Kun Chen

研究成果: 雜誌貢獻文章同行評審

32 引文 斯高帕斯(Scopus)


In this study, a photoresist template with well-defined contact hole array was fabricated, to which radio frequency magnetron sputtering process was then applied to deposit an alloyed Zr55Cu30Al10Ni5 target, and finally resulted in ordered metallic glass nanotube (MGNT) arrays after removal of the photoresist template. The thickness of the MGNT walls increased from 98 to 126 nm upon increasing the deposition time from 225 to 675 s. The wall thickness of the MGNT arrays also increased while the dimensions of MGNT reduced under the same deposition condition. The MGNT could be filled with biomacromolecules to change the effective refractive index. The air fraction of the medium layer were evaluated through static water contact angle measurements and, thereby, the effective refractive indices the transverse magnetic (TM) and transverse electric (TE) polarized modes were calculated. A standard biotin–streptavidin affinity model was tested using the MGNT arrays and the fundamental response of the system was investigated. Results show that filling the MGNT with streptavidin altered the effective refractive index of the layer, the angle of reflectance and color changes identified by an L*a*b* color space and color circle on an a*b* chromaticity diagram. The limit of detection (LOD) of the MGNT arrays for detection of streptavidin was estimated as 25 nM, with a detection time of 10 min. Thus, the MGNT arrays may be used as a versatile platform for high-sensitive label-free optical biosensing.
頁(從 - 到)129-135
期刊Biosensors and Bioelectronics
出版狀態已發佈 - 4月 15 2018

ASJC Scopus subject areas

  • 生物技術
  • 生物物理學
  • 生物醫學工程
  • 電化學


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