Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing

Fwu Long Mi, Shin Shing Shyu, Yu B. Wu, Sung T. Lee, Jen Y. Shyong, Rong N. Huang

研究成果: 雜誌貢獻文章同行評審

643 引文 斯高帕斯(Scopus)


A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin surface and porosity of sponge-like sublayer could be controlled by the modification of phase-separation process using per-evaporation method. The asymmetric chitosan membrane showed controlled evaporative water loss, excellent oxygen permeability and promoted fluid drainage ability but could inhibit exogenous microorganisms invasion due to the dense skin layer and inherent antimicrobial property of chitosan. Wound covered with the asymmetric chitosan membrane was hemostatic and healed quickly. Histological examination confirmed that epithelialization rate was increased and the deposition of collagen in the dermis was well organized by covering the wound with this asymmetric chitosan membrane. The results in this study indicate that the asymmetric chitosan membrane thus prepared could be adequately employed in the future as a wound dressing. Copyright (C) 2000 Elsevier Science B.V.

頁(從 - 到)165-173
出版狀態已發佈 - 1月 15 2001

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 生物醫學工程


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