Exploring the human gut microbiota targets in relation to the use of contemporary antidepressants

Shih Kai Kevin Lin, Hsi Chung Chen, Chun Hsin Chen, I. Ming Chen, Mong Liang Lu, Cheng Dien Hsu, Yi Hang Chiu, Tsung Yang Wang, Hui Mei Chen, Yu Chu Ella Chung, Po Hsiu Kuo

研究成果: 雜誌貢獻文章同行評審


Background: Antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are commonly prescribed for depression treatment. Animal studies have shown that antidepressants can influence gut microbiota composition and specific bacterial taxa. We aimed to investigate the association between antidepressant use and human gut microbiota composition and functional pathway. Methods: We collected information on antidepressant use, demographic, food patterns, and clinical characteristics through questionnaires and medical records. The gut microbiota profiles of 271 depressive patients were carried out through 16S rRNA gene sequencing. Patients were categorized based on different types of antidepressant use groups for gut microbiota comparisons. MaAsLin2 was performed to evaluate microbiota composition across groups. PICRUSt2 was used to predict microbiota functional pathways. Results: Patients taking SSRIs or SNRIs had a lower microbiota diversity. We found seven taxa abundances (Turicibacter, Barnesiella, Lachnospiraceae_ND3007_group, Romboutia, Akkermansia, Dialister, Romboutia and Fusicatenibacter) differed in patients with various types of antidepressants compared with those without antidepressant treatments (p < 0.05). Turicibacter inversely correlated with depression severity in SSRIs or SNRI users (r = −0.43, p < 0.05). Top identified pathways were related to compound fermentation and biosynthesis in microbiota function. Conclusion: Antidepressant usage, especially SSRIs and SNRIs, associates with changes in gut microbiota composition and specific taxa. Given our study's preliminary cross-sectional nature, further research is warranted to comprehend the relationship between antidepressant use, treatment response, and gut microbiota, aiming to enhance therapeutic interventions in the future.
頁(從 - 到)473-484
期刊Journal of Affective Disorders
出版狀態已發佈 - 1月 1 2024

ASJC Scopus subject areas

  • 臨床心理學
  • 精神病學和心理健康


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