Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

Y. H. Hsiang; L. F. Liu

Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

Y. H. Hsiang, L. F. Liu

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

Like many intercalative antitumor drugs, the nonintercalative antitumor drug epipodophyllotoxin VM-26 (teniposide) induces topoisomerase II-linked DNA breaks as revealed by cell lysis with a strong protein denaturant such as sodium dodecyl sulfate or alkali. We show that the majority of topoisomerase II-linked DNA breaks reflect the formation of reversible topoisomerase II-DNA cleavable complexes in drug-treated cells by demonstrating the reversibility of this unusual type of DNA damage at elevated temperatures (e.g. 65°C).

原文	英語
頁（從 - 到）	9713-9715
頁數	3
期刊	Journal of Biological Chemistry
卷	264
發行號	17
出版狀態	已發佈 - 1989
對外發佈	是

ASJC Scopus subject areas

生物化學
分子生物學
細胞生物學

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Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

摘要

ASJC Scopus subject areas

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