Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings

Jung Lung Hsu, Wen Chuin Hsu, Chiung Chih Chang, Kun Ju Lin, Ing Tsung Hsiao, Yen Chun Fan, Chyi Huey Bai

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer's disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = -0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = -0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = -0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = -0.41 and -0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.
原文英語
文章編號1719
期刊Scientific Reports
7
發行號1
DOIs
出版狀態已發佈 - 12月 1 2017

ASJC Scopus subject areas

  • 多學科

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