@article{98b8aeb490b84247bc2d3579f1287fb6,
title = "Evaluation of the grafting efficacy of active biomolecules of phosphatidylcholine and type i collagen on polyether ether ketone: In vitro and in vivo",
abstract = "Biomolecule grafting on polyether ether ketone (PEEK) was used to improve cell affinity caused by surface inertness. This study demonstrated the sequence-polished (P) and sulfonated (SA) PEEK modification to make a 3D structure, active biomolecule graftings through PEEK silylation (SA/SI) and then processed with phosphatidylcholine (with silylation of SA/SI/PC; without SA/PC) and type I collagen (COL I, with silylation of SA/SI/C; without SA/C). Different modified PEEKs were implanted for 4, 8, and 12 weeks for histology. Sulfonated PEEK of SA showed the surface roughness was significantly increased; after the silylation of SA/SI, the hydrophilic nature was remarkably improved. The biomolecules were effectively grafted through silylation, and the cells showed improved attachment after 1 h. Furthermore, the SA/SI/PC group showed good in vitro mineralization. The new bone tissues were integrated into the 3D porous structures of SA/SI/PC and SA/SI/C in vivo making PEEK a potential alternative to metals in orthopedic implants.",
keywords = "In vivo, Osteogenic, Phosphatidyl-choline, Polyether ether ketone, Surface modification, Type I collagen",
author = "Chen, {Jian Chih} and Chen, {Chih Hua} and Chang, {Kai Chi} and Liu, {Shih Ming} and Ko, {Chia Ling} and Shih, {Chi Jen} and Sun, {Ying Sui} and Chen, {Wen Cheng}",
note = "Funding Information: Funding: This research was major supported by the Ministry of Science and Technology, Taiwan (grant numbers MOST 109-2622-E-035-014-CC2, 106-2622-E-035-002-CC2 & 105-2622-E-035-006-CC2) and was funded partly by KMU research project (KMUH107-7R55 & KMUH108-8R50). Funding Information: This research was major supported by the Ministry of Science and Technology, Taiwan (grant numbers MOST 109-2622-E-035-014-CC2, 106-2622-E-035-002-CC2 & 105-2622-E-035-006-CC2) and was funded partly by KMU research project (KMUH107-7R55 & KMUH108-8R50).Acknowledgments: The authors acknowledge and appreciate the Precision Instrument Support Center of Feng Chia University, which provided the fabrication and measurement facilities. The assistance of the participants in this research is also acknowledged. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jul,
doi = "10.3390/polym13132081",
language = "English",
volume = "13",
journal = "Polymers",
issn = "2073-4360",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "13",
}