Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

K. T. Vu Thai; M. C. Yang; W. F. Lai

Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

K. T. Vu Thai, M. C. Yang, W. F. Lai

臺北醫學大學

研究成果: 書貢獻/報告類型 › 會議貢獻

1 引文斯高帕斯（Scopus）

摘要

An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.

原文	英語
主出版物標題	Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
頁面	187-190
頁數	4
卷	3
出版狀態	已發佈 - 2013
事件	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, 美国持續時間: 5月 12 2013 → 5月 16 2013

會議

會議	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
國家/地區	美国
城市	Washington, DC
期間	5/12/13 → 5/16/13

ASJC Scopus subject areas

生物技術

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Vu Thai, KT, Yang, MC & Lai, WF 2013, Evaluation of F127/chitosan hydrogel as a scaffold for bone repair. 於 Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. 卷 3, 頁 187-190, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, Washington, DC, 美国, 5/12/13.

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title = "Evaluation of F127/chitosan hydrogel as a scaffold for bone repair",

abstract = "An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.",

keywords = "Bone repair, Chitosan, F127, In situ forming gel, Viscoelastic properties",

author = "{Vu Thai}, {K. T.} and Yang, {M. C.} and Lai, {W. F.}",

year = "2013",

language = "English",

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volume = "3",

pages = "187--190",

booktitle = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",

note = "Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 ; Conference date: 12-05-2013 Through 16-05-2013",

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TY - GEN

T1 - Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

AU - Vu Thai, K. T.

AU - Yang, M. C.

AU - Lai, W. F.

PY - 2013

Y1 - 2013

N2 - An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.

AB - An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature due to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.

KW - Bone repair

KW - Chitosan

KW - F127

KW - In situ forming gel

KW - Viscoelastic properties

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M3 - Conference contribution

AN - SCOPUS:84881086115

SN - 9781482205862

VL - 3

SP - 187

EP - 190

BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

Y2 - 12 May 2013 through 16 May 2013

ER -

Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

摘要

會議

ASJC Scopus subject areas

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