@article{1455d7f9683042e780105ab8137d862b,
title = "Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)",
abstract = "Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.",
keywords = "Extracellular matrix, Fibronectin 1, Glycoprotein CD44, Integrin α4β1, Oral squamous cell carcinoma, Receiver-operating characteristic curves, Syndecan-2, Tumor marker",
author = "Yen, {Ching Yu} and Huang, {Chien Yang} and Hou, {Ming Feng} and Yang, {Yi Hsin} and Chang, {Chao Hsiang} and Huang, {Hurng Wern} and Chen, {Chung Ho} and Chang, {Hsueh Wei}",
note = "Funding Information: This work was partly supported by the National Science Council in Taiwan (under grant NSC97-2311-B-037-003-MY3), by the ChiMei-KMU joint fund (100CM-KMU-07), by the Department of Health (DOH101-TD-C-111-002), by the Kaohsiung Medical University Research Foundation (KMUER001 and KMU-M110001) and NSYSU-KMU Joint Research Project (#NSYSUKMU 101-006).",
year = "2013",
month = feb,
doi = "10.3109/1354750X.2012.737025",
language = "English",
volume = "18",
pages = "63--72",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Informa Healthcare",
number = "1",
}