TY - JOUR
T1 - Erlotinib in patients with advanced lung squamous cell carcinoma
AU - Chiang, Chi Lu
AU - Tsai, Chun Ming
AU - Chou, Teh Ying
AU - Chen, Yuh Min
AU - Lai, Shinn Liang
AU - Shih, Jen Fu
AU - Chiu, Chao Hua
AU - Lee, Yu Chin
PY - 2013/1
Y1 - 2013/1
N2 - Purpose: Erlotinib had proved efficacy in patients with advanced non-small cell lung cancer, especially adenocarcinoma. The aim of this study was to evaluate the efficacy of erlotinib in patients with advanced lung squamous cell carcinoma (LSQC). Methods: We retrospectively reviewed medical records and serial chest images of consecutive patients who were diagnosed with advanced LSQC and had been treated with erlotinib monotherapy. The primary objective was to evaluate the treatment efficacy and to correlate with patients' clinical characteristics. Results: Totally 55 patients were analyzed (42 men and 13 women, median age of 71 years). In 37 patients who had measurable lesions, 6 had partial response and 13 had stable disease, yielding an overall response rate of 16.2 % and disease control rate of 51.4 %. In all patients, the median progression-free survival (PFS) and overall survival (OS) were 2.0 months (95 % confidence interval, 1.5-2.4 months) and 10.4 months (95 % confidence interval, 0.6-20.2 months), respectively. The PFS and OS were significantly longer in patients who had good clinical response (either the tumor achieved partial response or the patients had disease controlled for more than 6 months) than those who did not (median PFS, 13.0 vs. 1.6 months; median OS, 28.3 vs. 4.9 months; both P values <0.01). Patients who never smoked seemed to have better clinical response and longer survival than those who had smoking history (P = 0.077 and 0.086, respectively). Conclusions: Erlotinib could provide some clinical benefit to patients with advanced LSQC.
AB - Purpose: Erlotinib had proved efficacy in patients with advanced non-small cell lung cancer, especially adenocarcinoma. The aim of this study was to evaluate the efficacy of erlotinib in patients with advanced lung squamous cell carcinoma (LSQC). Methods: We retrospectively reviewed medical records and serial chest images of consecutive patients who were diagnosed with advanced LSQC and had been treated with erlotinib monotherapy. The primary objective was to evaluate the treatment efficacy and to correlate with patients' clinical characteristics. Results: Totally 55 patients were analyzed (42 men and 13 women, median age of 71 years). In 37 patients who had measurable lesions, 6 had partial response and 13 had stable disease, yielding an overall response rate of 16.2 % and disease control rate of 51.4 %. In all patients, the median progression-free survival (PFS) and overall survival (OS) were 2.0 months (95 % confidence interval, 1.5-2.4 months) and 10.4 months (95 % confidence interval, 0.6-20.2 months), respectively. The PFS and OS were significantly longer in patients who had good clinical response (either the tumor achieved partial response or the patients had disease controlled for more than 6 months) than those who did not (median PFS, 13.0 vs. 1.6 months; median OS, 28.3 vs. 4.9 months; both P values <0.01). Patients who never smoked seemed to have better clinical response and longer survival than those who had smoking history (P = 0.077 and 0.086, respectively). Conclusions: Erlotinib could provide some clinical benefit to patients with advanced LSQC.
KW - Epidermal growth factor receptor
KW - Erlotinib
KW - Non-small cell lung cancer
KW - Squamous cell carcinoma
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U2 - 10.1007/s00280-012-1997-5
DO - 10.1007/s00280-012-1997-5
M3 - Article
C2 - 23053274
AN - SCOPUS:84872302178
SN - 0344-5704
VL - 71
SP - 203
EP - 208
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
IS - 1
ER -
