4 引文 斯高帕斯(Scopus)

摘要

The purpose of this study is to clarify the relationship between Epstein-Barr virus (EBV) and tumors of the major salivary gland. EBV DNA was detected by polymerase chain reaction (PCR) in parotid secretions in 56% of patients (n = 32) regardless of the presence of tumors in the parotid gland and in tumor tissues in 19% of surgical specimens (n = 21). By Southern blot-hybridization analysis, we found type A EBV in three patients and type B EBV in one patient. In situ hybridization for EBV genome was positive in surgical specimens of salivary glands in 33% of patients (n = 21). Our results suggest that this virus may not play a role in the pathogenesis of most tumors of the major salivary gland. However, two patients with lymphoepithelial carcinoma were found to have a close relationship to EBV as shown by high titers of antibodies in the sera against EBV related antigens by standard immunofluorescent technique and by the presence of many copies of EBV genome in tumor cells using in situ hybridization.

原文英語
頁(從 - 到)104-109
頁數6
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
93
發行號2
出版狀態已發佈 - 2月 1994

ASJC Scopus subject areas

  • 一般醫學

指紋

深入研究「Epstein-Barr virus harboring in the parotid gland without tumor association.」主題。共同形成了獨特的指紋。

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