@article{193d41b479f64ac5b548c8d0553ee631,
title = "Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients",
abstract = "Background: Endogenous estrogens play an important role in the overall cardiocirculatory system. However, there are no studies exploring the hormone metabolism and signaling pathway genes together on ischemic stroke, including sulfotransferase family 1E (SULT1E1), catechol-O-methyl-transferase (COMT), and estrogen receptor α (ESR1). Methods: A case-control study was conducted on 305 young ischemic stroke subjects aged ≦ 50 years and 309 age-matched healthy controls. SULT1E1 -64G/A, COMT Val158Met, ESR1 c.454-397 T/C and c.454-351 A/G genes were genotyped and compared between cases and controls to identify single nucleotide polymorphisms associated with ischemic stroke susceptibility. Gene-gene interaction effects were analyzed using entropy-based multifactor dimensionality reduction (MDR), classification and regression tree (CART), and traditional multiple regression models. Results: COMT Val158Met polymorphism showed a significant association with susceptibility of young ischemic stroke among females. There was a two-way interaction between SULT1E1 -64G/A and COMT Val158Met in both MDR and CART analysis. The logistic regression model also showed there was a significant interaction effect between SULT1E1 -64G/A and COMT Val158Met on ischemic stroke of the young (P for interaction = 0.0171). We further found that lower estradiol level could increase the risk of young ischemic stroke for those who carry either SULT1E1 or COMT risk genotypes, showing a significant interaction effect (P for interaction = 0.0174). Conclusions: Our findings support that a significant epistasis effect exists among estrogen metabolic and signaling pathway genes and gene-environment interactions on young ischemic stroke subjects.",
author = "Hsieh, {Yi Chen} and Jeng, {Jiann Shing} and Lin, {Huey Juan} and Hu, {Chaur Jong} and Yu, {Chia Chen} and Lien, {Li Ming} and Peng, {Giia Sheun} and Chen, {C. I Chin I} and Tang, {Sung Chun} and Chi, {Nai Fang} and Tseng, {Hung Pin} and Chern, {Chang Ming} and Hsieh, {F. I Fang I} and Bai, {Chyi Huey} and Chen, {Yi Rhu} and Chiou, {Hung Yi} and Jeng, {Jiann Shing} and Tang, {Sung Chun} and Yeh, {Shin Joe} and Tsai, {Li Kai} and Shin Kong and Lien, {Li Ming} and Chiu, {Hou Chang} and Chen, {Wei Hung} and Bai, {Chyi Huey} and Huang, {Tzu Hsuan} and Lau, {Chi Ieong} and Wu, {Ya Ying} and Yuan, {Rey Yue} and Hu, {Chaur Jong} and Sheu, {Jau Jiuan} and Yu, {Jia Ming} and Ho, {Chun Sum} and Chen, {Chin I.} and Sung, {Jia Ying} and Weng, {Hsing Yu} and Han, {Yu Hsuan} and Huang, {Chun Ping} and Chung, {Wen Ting} and Ke, {Der Shin} and Lin, {Huey Juan} and Chang, {Chia Yu} and Yeh, {Poh Shiow} and Lin, {Kao Chang} and Cheng, {Tain Junn} and Chou, {Chih Ho} and Yang, {Chun Ming} and Peng, {Giia Sheun} and Lin, {Jiann Chyun} and Hsu, {Yaw Don} and Denq, {Jong Chyou} and Lee, {Jiunn Tay} and Hsu, {Chang Hung} and Lin, {Chun Chieh} and Yen, {Che Hung} and Cheng, {Chun An} and Sung, {Yueh Feng} and Chen, {Yuan Liang} and Lien, {Ming Tung} and Chou, {Chung Hsing} and Liu, {Chia Chen} and Yang, {Fu Chi} and Wu, {Yi Chung} and Tso, {An Chen} and Lai, {Yu Hua} and Chiang, {Chun I.} and Tsai, {Chia Kuang} and Liu, {Meng Ta} and Lin, {Ying Che} and Hsu, {Yu Chuan} and Chen, {Chih Hung} and Sung, {Pi Shan} and Chern, {Chang Ming} and Hu, {Han Hwa} and Wong, {Wen Jang} and Luk, {Yun On} and Hsu, {Li Chi} and Chung, {Chih Ping} and Tseng, {Hung Pin} and Liu, {Chin Hsiung} and Lin, {Chun Liang} and Lin, {Hung Chih} and Hu, {Chaur Jong}",
year = "2012",
month = oct,
day = "24",
doi = "10.1371/journal.pone.0047773",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",
}