(-)Epigallocatechin-3-gallate decreases the stress-induced impairment of learning and memory in rats

Hung Sheng Soung, Mao Hsien Wang, Hsiang Chien Tseng, Hsu Wei Fang, Kuo Chi Chang

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)


Stress induces reactive oxygen species (ROS) and causes alterations in brain cytoarchitecture and cognition. Green tea has potent antioxidative properties especially the tea catechin (-) epigallocatechin-3-gallate (EGCG). These powerful antioxidative properties are able to protect against various oxidative damages. In this study we investigated the impact of stress on rats' locomotor activity, learning and memory. Many tea catechins, including EGCG, were examined for their possible therapeutic effects in treating stress-induced impairment. Our results indicated that locomotor activity was decreased, and the learning and memory were impaired in stressed rats (SRs). EGCG treatment was able to prevent the decreased locomotor activity as well as improve the learning and memory in SRs. EGCG treatment was also able to reduce the increased oxidative status in SRs' hippocampi. The above results suggest a therapeutic effect of EGCG in treating stress-induced impairment of learning and memory, most likely by means of its powerful antioxidative properties.
頁(從 - 到)27-32
期刊Neuroscience Letters
出版狀態已發佈 - 8月 8 2015

ASJC Scopus subject areas

  • 一般神經科學


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