Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

Yu Chien Lin, Huey Yuan Wang, Yao Chun Tang, Wan Rong Lin, Ching Li Tseng, Chih Chien Hu, Ren Jei Chung

研究成果: 雜誌貢獻文章同行評審

摘要

Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. Dopamine (DP) was introduced to this hybrid (G-H-D) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-D material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing.
原文英語
文章編號128845
期刊International Journal of Biological Macromolecules
258
DOIs
出版狀態已發佈 - 2月 2024

ASJC Scopus subject areas

  • 結構生物學
  • 生物化學
  • 分子生物學

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