TY - JOUR
T1 - Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2
AU - Singh, Vijendra K.
AU - Leu, Sy Jye Christine
PY - 1990/12/11
Y1 - 1990/12/11
N2 - Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.
AB - Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.
KW - Corticotropin-releasing factor
KW - Interleukin production
KW - Neuroimmunomodulation
UR - http://www.scopus.com/inward/record.url?scp=0025705776&partnerID=8YFLogxK
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U2 - 10.1016/0304-3940(90)90025-5
DO - 10.1016/0304-3940(90)90025-5
M3 - Article
C2 - 2293102
AN - SCOPUS:0025705776
SN - 0304-3940
VL - 120
SP - 151
EP - 154
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -