@article{525a9a270b464ce69bcb4b19f0042876,
title = "Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036",
abstract = "D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.",
keywords = "DNA double strand breaks, Drug resistance, Selenophene",
author = "Yang, {Yung Ning} and Chou, {Kai ming} and Pan, {Wen Yu} and Chen, {Yih wen} and Tsou, {Tsui Chun} and Yeh, {Ssu Ching} and Cheung, {Chun Hei Antonio} and Chen, {Li Tzong} and Chang, {Jang Yang}",
note = "Funding Information: This study was supported by Grants of National Science Council ( NSC98-2323-B-400-004 and NSC99-2120-M-006-005 ), and Department of Health ( DOH99-TD-C-111-004 ), Taiwan, ROC. K.-M. Chou is supported by National Institutes of Health (NIH) Grant RO1 CA112446. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",
year = "2011",
month = oct,
doi = "10.1016/j.canlet.2011.05.023",
language = "English",
volume = "309",
pages = "110--118",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}
