Enhanced Prediction of mRNA Subcellular Localization Using a Novel Ensemble Learning and Hybrid Approach

Thi Tuyen Nguyen, Van Nui Nguyen, Thi Xuan Tran, Nguyen Quoc Khanh Le

研究成果: 書貢獻/報告類型會議貢獻

摘要

Unraveling the subcellular localization of mRNA is an imperative aspect in the realm of biotechnology. This resolution can illuminate the inner workings of genetic regulatory mechanisms, gene expression modalities, and the evolution of cellular physiological and developmental processes. However, the experimental delineation of mRNA subcellular localization imposes significant temporal and resource commitments. Despite the development of multiple algorithms and predictive models for mRNA subcellular localization, their performance indexes have not been markedly high. In this paper, we introduce a novel hybrid approach to categorize mRNA into five distinct subcellular locales, including the cytoplasm, endoplasmic reticulum, extracellular region, mitochondria, and nucleus. Our model exploits the strengths of ensemble learning with a hybrid methodology, incorporating multiple biologically pertinent features extracted from the input sequencing data. Additionally, the model dynamically adjusts the weightages of functions and the minority class, through the modulation of the weight ratio of disparate models during their contribution to the principal model. Overall, our model delivers promising results, with an average accuracy of 0.89 in an independent dataset for the classification of mRNA subcellular localizations into five subclasses. This displays a significant performance elevation in contrast to preceding algorithms, particularly in instances where the classes are adequately sampled.
原文英語
主出版物標題Advances in Information and Communication Technology - Proceedings of the 2nd International Conference ICTA 2023
編輯Phung Trung Nghia, Vu Duc Thai, Nguyen Thanh Thuy, Le Hoang Son, Van-Nam Huynh
發行者Springer Science and Business Media Deutschland GmbH
頁面60-68
頁數9
ISBN(列印)9783031495281
DOIs
出版狀態已發佈 - 2023
事件2nd International Conference on Advances in Information and Communication Technology, ICTA 2023 - Thai Nguyen, 越南
持續時間: 12月 13 202312月 14 2023

出版系列

名字Lecture Notes in Networks and Systems
847 LNNS
ISSN(列印)2367-3370
ISSN(電子)2367-3389

會議

會議2nd International Conference on Advances in Information and Communication Technology, ICTA 2023
國家/地區越南
城市Thai Nguyen
期間12/13/2312/14/23

ASJC Scopus subject areas

  • 控制與系統工程
  • 訊號處理
  • 電腦網路與通信

指紋

深入研究「Enhanced Prediction of mRNA Subcellular Localization Using a Novel Ensemble Learning and Hybrid Approach」主題。共同形成了獨特的指紋。

引用此