Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Cheng Hsun Wu; Yi-Ping Chen; Si-Han Wu; Yann Hung; Chung Yuan Mou; Richard P. Cheng

doi:10.1021/am4039882

Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Cheng Hsun Wu, Yi-Ping Chen, Si-Han Wu, Yann Hung, Chung Yuan Mou, Richard P. Cheng

研究成果: 雜誌貢獻 › 文章 › 同行評審

20 引文斯高帕斯（Scopus）

摘要

Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

原文	英語
頁（從 - 到）	12244-12248
頁數	5
期刊	ACS Applied Materials and Interfaces
卷	5
發行號	23
DOIs	https://doi.org/10.1021/am4039882
出版狀態	已發佈 - 12月 11 2013
對外發佈	是

ASJC Scopus subject areas

材料科學(全部)
醫藥 (全部)

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10.1021/am4039882

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引用此

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AU - Mou, Chung Yuan

AU - Cheng, Richard P.

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AB - Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

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Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

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