TY - JOUR
T1 - Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles
AU - Lu, Kun Ying
AU - Jheng, Pei Ru
AU - Lu, Long Sheng
AU - Rethi, Lekshmi
AU - Mi, Fwu Long
AU - Chuang, Er Yuan
N1 - Funding Information:
This research work was financially supported by the Taiwan Ministry of Science and Technology (grant numbers: 108-2221-E-038-004 , 108-2320-B-038-061-MY3 , and 108-2221-E-038-017-MY3 ).
Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Nanomaterial mediated cancer/tumor photo driven hyperthermia has obtained great awareness. Nevertheless, it is a challenge for improving the hyperthermic efficacy lacking resistance to stimulated thermal stress. We thus developed a bioinspired nano-platform utilizing inclusion complexation between photosensitive polypyrrole (Ppy) nanoparticles (NP) and fucoidan (FU). This FU-Ppy NP proved to be an excellent P-selectin-mediated, lung cancer-cell/tumor targeting delivery and specific accumulation, could augment cancer/tumor oxidative stress levels through producing cellular reactive oxygen species. Potent ROS/photothermal combinational therapeutic effects were exhibited by the bioinspired FU-Ppy NP through a selective P-selectin cancer/tumor targeting aptitude for the lung cancer cells/tumor compared with other nano-formulations. The usage of FU-Ppy NP also involves the potential mechanism of suppressing the biological expression of tumor vascular endothelial growth factor (VEGF). This FU biological macromolecule-amplified photothermally therapeutic nano-platform has promising potential for future medical translation in eradicating numerous tumors.
AB - Nanomaterial mediated cancer/tumor photo driven hyperthermia has obtained great awareness. Nevertheless, it is a challenge for improving the hyperthermic efficacy lacking resistance to stimulated thermal stress. We thus developed a bioinspired nano-platform utilizing inclusion complexation between photosensitive polypyrrole (Ppy) nanoparticles (NP) and fucoidan (FU). This FU-Ppy NP proved to be an excellent P-selectin-mediated, lung cancer-cell/tumor targeting delivery and specific accumulation, could augment cancer/tumor oxidative stress levels through producing cellular reactive oxygen species. Potent ROS/photothermal combinational therapeutic effects were exhibited by the bioinspired FU-Ppy NP through a selective P-selectin cancer/tumor targeting aptitude for the lung cancer cells/tumor compared with other nano-formulations. The usage of FU-Ppy NP also involves the potential mechanism of suppressing the biological expression of tumor vascular endothelial growth factor (VEGF). This FU biological macromolecule-amplified photothermally therapeutic nano-platform has promising potential for future medical translation in eradicating numerous tumors.
KW - Anticancer
KW - Fucoidan polypyrrole nanoparticles
KW - p-Selectin mediated cancer delivery
KW - ROS boosted photothermal therapy
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=85095827964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85095827964&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2020.10.091
DO - 10.1016/j.ijbiomac.2020.10.091
M3 - Article
C2 - 33091478
AN - SCOPUS:85095827964
SN - 0141-8130
VL - 166
SP - 98
EP - 107
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -
