Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

Ching Yao Yang; Ming Huei Fan; Carol H. Miao; Yi Jen Liao; Ray Hwang Yuan; Chao Lien Liu

doi:10.1016/j.omto.2020.05.009

Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

Ching Yao Yang
, Ming Huei Fan
, Carol H. Miao
, Yi Jen Liao
, Ray Hwang Yuan
, Chao Lien Liu

研究成果: 雜誌貢獻 › 文章 › 同行評審

56 引文斯高帕斯（Scopus）

摘要

Yang et al. developed armed third-generation PD-L1-targeted ACR/CAR T cells utilizing a PD-1/PD-L1 immune checkpoint axis. Both engineered CAR T cells significantly improved tumor control and survival in models of PD-L1-expressed pancreatic cancers.

原文	英語
頁（從 - 到）	571-585
頁數	15
期刊	Molecular Therapy - Oncolytics
卷	17
DOIs	https://doi.org/10.1016/j.omto.2020.05.009
出版狀態	已發佈 - 6月 26 2020

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

ASJC Scopus subject areas

分子醫學
腫瘤科
癌症研究
藥學（醫學）

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10.1016/j.omto.2020.05.009

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Link to publication in Scopus

引用此

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title = "Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer",

abstract = "Yang et al. developed armed third-generation PD-L1-targeted ACR/CAR T cells utilizing a PD-1/PD-L1 immune checkpoint axis. Both engineered CAR T cells significantly improved tumor control and survival in models of PD-L1-expressed pancreatic cancers.",

keywords = "ACR, CAR, PD-1, PD-L1, PDAC",

author = "Yang, \{Ching Yao\} and Fan, \{Ming Huei\} and Miao, \{Carol H.\} and Liao, \{Yi Jen\} and Yuan, \{Ray Hwang\} and Liu, \{Chao Lien\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = jun,

day = "26",

doi = "10.1016/j.omto.2020.05.009",

language = "English",

volume = "17",

pages = "571--585",

journal = "Molecular Therapy - Oncolytics",

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T1 - Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

AU - Yang, Ching Yao

AU - Fan, Ming Huei

AU - Miao, Carol H.

AU - Liao, Yi Jen

AU - Yuan, Ray Hwang

AU - Liu, Chao Lien

PY - 2020/6/26

Y1 - 2020/6/26

N2 - Yang et al. developed armed third-generation PD-L1-targeted ACR/CAR T cells utilizing a PD-1/PD-L1 immune checkpoint axis. Both engineered CAR T cells significantly improved tumor control and survival in models of PD-L1-expressed pancreatic cancers.

AB - Yang et al. developed armed third-generation PD-L1-targeted ACR/CAR T cells utilizing a PD-1/PD-L1 immune checkpoint axis. Both engineered CAR T cells significantly improved tumor control and survival in models of PD-L1-expressed pancreatic cancers.

KW - ACR

KW - CAR

KW - PD-1

KW - PD-L1

KW - PDAC

UR - https://www.scopus.com/pages/publications/85087048001

UR - https://www.scopus.com/pages/publications/85087048001#tab=citedBy

U2 - 10.1016/j.omto.2020.05.009

DO - 10.1016/j.omto.2020.05.009

M3 - Article

AN - SCOPUS:85087048001

SN - 2372-7705

VL - 17

SP - 571

EP - 585

JO - Molecular Therapy - Oncolytics

JF - Molecular Therapy - Oncolytics

ER -

Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

摘要

UN SDG

ASJC Scopus subject areas

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引用此