@article{7b1c7a55f1a64b20af6ae42bf3fbdd8b,
title = "End stage renal disease is associated with development of dementia",
abstract = "There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.",
keywords = "Alzheimer's disease, Dementia, End stage renal disease, Gerotarget, Hemodialysis, Peritoneal dialysis",
author = "Hung, {Peir Haur} and Yeh, {Chih Ching} and Hsiao, {Chih Yen} and Sung, {Pi Shan} and Muo, {Chih Hsin} and Sung, {Fung Chang} and Hung, {Kuan Yu} and Tsai, {Kuen Jer}",
note = "Funding Information: This study was supported in part by the National Cheng Kung University, Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW105-TDU-B-212-133019), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037), NRPB Stroke Clinical Trial Consortium (MOST 104-2325-B-039-005), Tseng-Lien Lin Foundation (Taichung, Taiwan), Taiwan Brain Disease Foundation (Taipei, Taiwan), and Katsuzo and Kiyo Aoshima Memorial Funds (Japan). Publisher Copyright: {\textcopyright} Hung et al.",
year = "2017",
month = jan,
day = "1",
doi = "10.18632/oncotarget.22458",
language = "English",
volume = "8",
pages = "107348--107355",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "64",
}