Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su, Shur Hueih Cherng, Chien Chung Chen, Huei Lee

研究成果: 雜誌貢獻文章同行評審

46 引文 斯高帕斯(Scopus)


Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
頁(從 - 到)205-212
期刊Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
出版狀態已發佈 - 7月 1995

ASJC Scopus subject areas

  • 遺傳學
  • 分子生物學
  • 健康、毒理學和誘變


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