@article{5192bcb808c7433cb2c32afa3fc94d59,
title = "Emerging nano-carrier strategies for brain tumor drug delivery and considerations for clinical translation",
abstract = "Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still uncommon in clinical use despite decades of research and development. Here, we provide an update on nano-carrier strategies for improving brain drug delivery for treatment of brain tumors, focusing on liposomes, extracellular vesicles and biomimetic strategies as the most clinically feasible strategies. Finally, we describe the obstacles in translation of these technologies including pre-clinical models, analytical methods and regulatory issues.",
keywords = "Blood–brain barrier, Brain tumor, Exosome, Glioblastoma multiforme, Liposome, Nanomedicine",
author = "Lundy, {David J.} and Helen Nguyễn and Hsieh, {Patrick C.H.}",
note = "Funding Information: The authors are supported by the Ministry of Science and Technology, Taiwan (109-2321-B-001-012, 109-2327-B-001-001, 109-2740-B-001-002, MOST 110-2740-B-001-003, MOST 109-2636-B-038-003), the National Health Research Institutes (EX109-10907SI), and the Academia Sinica Healthy Longevity Grand Challenge (AS-HLGC-109-05), Translational Medical Research Program (AS-KPQ-110-BioMed) and Taipei Medical University-CWRU Pilot Program (108-3805-023-400). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = aug,
doi = "10.3390/pharmaceutics13081193",
language = "English",
volume = "13",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",
}