Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behavior

Yen Jen Wang, Teng Yuan Lo, Chieh Hsi Wu, Dean Mo Liu

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)


In this communication, we report a facile nanotopographical control over a stainless steel surface via an electrophoretic deposition of colloidal amphiphilic chitosan for preferential growth, proliferation or migration of vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs). Atomic force microscopy revealed that the colloidal surface exhibited a deposition time-dependent nanotopographical evolution, wherein two different nanotopographic textures indexed by 'kurtosis' (Rkur) value were easily designed, which were termed as 'sharp' (i.e. high peak-to-valley texture) surface and 'flat' (i.e. low peak-to-valley texture) surface. Cellular behaviour of VSMCs and HUVECs on both surfaces demonstrated topographically dependent morphogenesis, adherent responses and biochemical properties in comparison with bare stainless steel. The formation of a biofunctionalized surface upon a facile colloidal chitosan deposition envisions the potential application towards numerous biomedical devices, and this is especially promising for cardiovascular stents wherein a new surface with optimized texture can be designed and is expected to create an advantageous environment to stimulate HUVEC growth for improved healing performance.

期刊Journal of the Royal Society Interface
出版狀態已發佈 - 9月 6 2013

ASJC Scopus subject areas

  • 生物物理學
  • 生物技術
  • 生物工程
  • 生物醫學工程
  • 生物材料
  • 生物化學
  • 醫藥 (全部)


深入研究「Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behavior」主題。共同形成了獨特的指紋。