TY - JOUR
T1 - Efficacy of Platelet-Rich Plasma Injection on Range of Motion, Pain, and Disability in Patients With Adhesive Capsulitis
T2 - A Systematic Review and Meta-analysis
AU - Lin, Ho Wei
AU - Tam, Ka Wai
AU - Liou, Tsan Hon
AU - Rau, Chi Lun
AU - Huang, Shih Wei
AU - Hsu, Tzu Herng
N1 - Publisher Copyright:
© 2023 American Congress of Rehabilitation Medicine
PY - 2023/12
Y1 - 2023/12
N2 - Objective: To investigate the therapeutic effects of platelet-rich plasma (PRP) injection on range of motion, pain, and disability in patients with adhesive capsulitis (AC). Data Sources: The authors performed the literature search in the PubMed, Embase, and Cochrane Library databases in February 2023. Study Selection: Prospective studies comparing the outcomes of PRP with other intervention in patients with AC. Data Extraction: The quality of included randomized trials was assessed using the revised Cochrane Risk of Bias (RoB 2.0) tool. The Risk of Bias in Non-Randomized Studies of Interventions tool was applied to assess the quality of nonrandomized trials. The mean difference (MD) or standardized mean difference (SMD) was determined as the effect size for continuous outcomes, and outcome accuracy was determined using 95% confidence intervals (CIs). Data Synthesis: Fourteen studies involving 1139 patients were included. Our meta-analysis revealed that PRP injection can significantly improve passive abduction (MD=3.91; 95% CI, 0.84-6.98), passive flexion (MD=3.90; 95% CI, 0.15-7.84), and disability (SMD=−0.50; 95% CI, −1.29 to −0.74) within 1 month after intervention. Moreover, PRP injection can significantly improve passive abduction (MD=17.19; 95% CI, 12.38-22.01), passive flexion (MD=17.74; 95% CI, 9.89-25.59), passive external rotation (MD=12.95; 95% CI, 10.04-15.87), pain (MD=−8.40; 95% CI, −16.73 to −0.06), and disability (SMD=−1.02; 95% CI, −1.29 to −0.74) 3 months after intervention. PRP injection can also significantly improve pain (MD=−18.98; 95% CI, −24.71 to −13.26), and disability (SMD=−2.01; 95% CI, −3.02 to −1.00) 6 months after intervention. In addition, no adverse effects of PRP injection were reported. Conclusions: PRP injection may serve as an effective and safe treatment for patients with AC.
AB - Objective: To investigate the therapeutic effects of platelet-rich plasma (PRP) injection on range of motion, pain, and disability in patients with adhesive capsulitis (AC). Data Sources: The authors performed the literature search in the PubMed, Embase, and Cochrane Library databases in February 2023. Study Selection: Prospective studies comparing the outcomes of PRP with other intervention in patients with AC. Data Extraction: The quality of included randomized trials was assessed using the revised Cochrane Risk of Bias (RoB 2.0) tool. The Risk of Bias in Non-Randomized Studies of Interventions tool was applied to assess the quality of nonrandomized trials. The mean difference (MD) or standardized mean difference (SMD) was determined as the effect size for continuous outcomes, and outcome accuracy was determined using 95% confidence intervals (CIs). Data Synthesis: Fourteen studies involving 1139 patients were included. Our meta-analysis revealed that PRP injection can significantly improve passive abduction (MD=3.91; 95% CI, 0.84-6.98), passive flexion (MD=3.90; 95% CI, 0.15-7.84), and disability (SMD=−0.50; 95% CI, −1.29 to −0.74) within 1 month after intervention. Moreover, PRP injection can significantly improve passive abduction (MD=17.19; 95% CI, 12.38-22.01), passive flexion (MD=17.74; 95% CI, 9.89-25.59), passive external rotation (MD=12.95; 95% CI, 10.04-15.87), pain (MD=−8.40; 95% CI, −16.73 to −0.06), and disability (SMD=−1.02; 95% CI, −1.29 to −0.74) 3 months after intervention. PRP injection can also significantly improve pain (MD=−18.98; 95% CI, −24.71 to −13.26), and disability (SMD=−2.01; 95% CI, −3.02 to −1.00) 6 months after intervention. In addition, no adverse effects of PRP injection were reported. Conclusions: PRP injection may serve as an effective and safe treatment for patients with AC.
KW - Bursitis
KW - Pain
KW - Platelet-rich plasma
KW - Range of motion, articular
KW - Rehabilitation
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U2 - 10.1016/j.apmr.2023.03.032
DO - 10.1016/j.apmr.2023.03.032
M3 - Review article
C2 - 37119955
AN - SCOPUS:85160289885
SN - 0003-9993
VL - 104
SP - 2109
EP - 2122
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 12
ER -