Effects of lidocaine on rat's isolated tracheal smooth muscle

Chuan Hsiang Kao, Yueng Hsiang Chu, Hsing Won Wang

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)


Lidocaine has been used as an injection or spray solution to protect spasm reaction during tracheal intubation and bronchoscopy. The effect of lidocaine for local anesthesia is well known. However, the effect of the drug to tracheal smooth muscle is not well explored. We used our preparation to test the effectiveness of lidocaine on rat's isolated tracheal smooth muscle. The following assessments of lidocaine were performed: (1) effect on tracheal smooth muscle resting tension; (2) effect on contraction caused by 5 × 10 -6 M methacholine as a parasympathetic mimetic; (3) effect of lidocaine on electrically induced tracheal smooth muscle contractions. The addition of lidocaine induced a relaxation response to methacholineinduced contraction. Low doses of the drug resulted in a slight decrease in contraction and higher doses relaxed the trachea much more quickly. At 10-3 M of lidocaine, almost 51% of 5 × 10-6 M methacholine-induced contraction was decreased. Using the same concentration, the drug also could totally inhibit the electrical Weld stimulation-induced spike contraction. Lidocaine elicited a negligible response to the resting tension of trachea as the concentration increased. The study indicated that lidocaine could cause bronchodilation not only from blocking parasympathetic tone, but also from directly antagonizing the effect of cholinergic receptors.

頁(從 - 到)817-820
期刊European Archives of Oto-Rhino-Laryngology
出版狀態已發佈 - 5月 2010

ASJC Scopus subject areas

  • 耳鼻咽喉科


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