添加異麥芽寡醣管灌配方對於慢性臥床使用呼吸器病患腸道功能及菌相之影響

In this study we examined the effects of isomaltose oligosaccharide (IMO) supplementation by tube-feeding on intestinal functions and flora in chronic bedridden patients on respirators. Twenty subjects aged ＞45 years old undergoing tube feeding were recruited for this randomized crossover study. One week after being given Isocal HN and Jevity HN Abbott formula, 10 subjects were given tube feeding with 10 g IMO supplementation every morning for 4 weeks, and then switched to tube feeding without IMO supplementation for 4 weeks after a 2-week washout period, and this protocol was reversed for the other 10 subjects. Blood and fecal samples were collected 1 week before the experiment, at weeks 0, 2, 4, 6, 8, and 10 for further analyses, and gastrointestinal function was recorded. Results showed that blood hemoglobin, albumin, fecal weight, water content, and amounts of Lactobacillus and Bifidobacterium in the feces significantly increased in subjects given tube feeding with IMO supplementation in weeks 4 and 10 (＜0.05). However, the amount of Clostridium perfringens was decreased (＜0.05). Therefore, IMO supplementation enhanced the intestinal probiotic Bifidobacterium, increased the amount of Lactobacillus, decreased the amount of Clostridium perfringens, and improved fecal excretion.