Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice

Yunru Liu, Qiongjun Xu, Yaping Ma

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.

METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.

RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).

CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.

原文英語
頁(從 - 到)376-377
頁數2
期刊Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
32
發行號5
出版狀態已發佈 - 5月 1 2014
對外發佈

ASJC Scopus subject areas

  • 一般醫學

指紋

深入研究「Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice」主題。共同形成了獨特的指紋。

引用此