TY - JOUR
T1 - Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats
AU - Wen-Chang, Chang
AU - Junko, Nakao
AU - Tomohiro, Neichi
AU - Hajime, Orimo
AU - Sei-Itsu, Murota
PY - 1981/5/22
Y1 - 1981/5/22
N2 - We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.
AB - We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.
KW - (Rat aorta, Platelet)
KW - Arachidonate metabolism
KW - Atherosclerosis
KW - Estradiol
KW - Prostacyclin production
KW - Thromboxane synthesis
UR - http://www.scopus.com/inward/record.url?scp=0019863229&partnerID=8YFLogxK
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U2 - 10.1016/0005-2760(81)90052-7
DO - 10.1016/0005-2760(81)90052-7
M3 - Article
C2 - 6788092
AN - SCOPUS:0019863229
SN - 1388-1981
VL - 664
SP - 291
EP - 297
JO - BBA - Specialised Section On Lipids and Related Subjects
JF - BBA - Specialised Section On Lipids and Related Subjects
IS - 2
ER -