Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice

Sen Wei Tsai, Yi Ju Hsu, Mon Chien Lee, Hao En Huang, Chi Chang Huang, Yu Tang Tung

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)


Current treatment options for muscle injuries remain suboptimal and often result in delayed/incomplete recovery of damaged muscles. In this study, the effects of dextrose prolotherapy on inflammation and regeneration of skeletal muscles after a contusion injury were investigated. Mice were separated into five groups, including a normal control (NC), post-injury with no treatment (mass-drop injury, MDI), post-injury with 10% dextrose (MDI + 10% dextrose), post-injury with 20% dextrose (MDI + 20% dextrose), and post-injury with 30% dextrose (MDI + 30% dextrose). The gastrocnemius muscles of the mice were subjected to an MDI, and muscle samples were collected at 7 days post-injury. Results showed the serum creatine kinase (CK), blood urea nitrogen (BUN), creatinine (CREA), and low-density lipoprotein (LDH) of the MDI-alone group were significantly higher than those of the normal control group (p<0.05). However, levels of serum CK, BUN, CREA, and lactate dehydrogenase (LDH) significantly decreased with different concentrations of dextrose. In addition, dextrose suppressed the macrophage response (F4/80 protein decreased) and promoted muscle satellite cell regeneration (desmin protein increased). In conclusion, dextrose prolotherapy can effectively help repair muscles; therefore, it may be one of the methods for clinically treating muscle injuries.

頁(從 - 到)1251-1259
期刊International Journal of Medical Sciences
出版狀態已發佈 - 7月 30 2018

ASJC Scopus subject areas

  • 一般醫學


深入研究「Effects of dextrose prolotherapy on contusion-induced muscle injuries in mice」主題。共同形成了獨特的指紋。