Effects of Bupivacaine on the Isolated Rat Tracheal Smooth Muscle

Ying Nan Chang, Chih Hung Wang, Chi Chung Wu, Hsing Won Wang

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)


Background: Bupivacaine is an amide-linked local anesthetic that has been used in subcutaneous infiltration, epidural and peripheral nerve block for surgery over three decades. Several studies have suggested that inhaled local anesthetics can reduce respiratory reflexes. To assess the direct actions of bupivacaine on airway smooth muscle we used our preparation to examine the effectiveness of bupivacaine on isolated rat trachea. Methods: A 5-mm-long portion of rat trachea was mounted in Krebs solution at 37°C. Changes in tracheal contractility in response to a parasympathetic mimetic agent and electrical stimulation were measured using a transducer connected to a Pentium III computer equipped with polygraphy software. The following assessments were done: (1) effect of bupivacaine on the resting tension of tracheal smooth muscle; (2) effect of bupivacaine on contraction caused by exposure to 10 -6M methacholine as a parasympathetic mimetic; (3) effect of bupivacaine on electrically induced contraction of tracheal smooth muscle. Results: Bupivacaine had a negligible effect on the basal tracheal tension as the concentration increased. Bupivacaine inhibited the tracheal smooth muscle contraction in response to methacholine and electrical stimulation in a concentration-dependent manner. Conclusion: The study indicates that bupivacaine might inhibit cholinergic neurotransmission and have an anti-spasmic effect on the trachea, in that it inhibited the contractions elicited by electrical field stimulation and a depolarizing agent.

頁(從 - 到)62-65
期刊Journal of Experimental and Clinical Medicine(Taiwan)
出版狀態已發佈 - 2月 2012

ASJC Scopus subject areas

  • 一般醫學


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