Effect of Patient Decision Aids on Choice Between Sugammadex and Neostigmine in Surgical Patients Under General Anesthesia: A Multicenter Randomized Controlled Trial

Li-Kai Wang, Yao-Tsung Lin, Jui-Tai Chen, Winnie Lan, Kuo-Chuan Hung, Jen-Yin Chen, Kuei-Jung Liu, Yu-Chun Yen, Yun-Yun Chou, Yih-Giun Cherng, Ka-Wai Tam

研究成果: 雜誌貢獻文章同行評審


Background: Shared decision-making using patient decision aids (PtDAs) has been established for more than a decade, but few studies have evaluated its efficacy in Asian countries. We evaluated the application of PtDAs in a decision conflict between two muscle relaxant reversal agents—neostigmine and sugammadex—and performed sequential analysis for hospital location and operating room turnover rate. Methods: This two-group, outcome assessor–blind, randomized controlled trial included 3132 surgical patients from two medical centres, admitted between March 2020 and August 2020. The patients were randomly divided into classical explanation and PtDAs-assisted explanation groups in preanesthesia consultations. Their clinicodemographic characteristics were analysed to identify the variables influencing their choice of reversal agent. On the day of preanesthesia consultations, the patients’ decision-making difficulties were assessed using a four-item SURE scale. The operating turnover rate were evaluated according to the anesthesia records. Results: Compared with the classical group, the patients in the PtDAs group felt more confident about receiving sufficient medical information (P < 0.001), were better informed about advantages and disadvantages of the medications (P < 0.001), had superior understanding of benefits and risk of their options (P < 0.001), and had a firm attitude toward their choices (P < 0.001). Moreover, the PtDAs group had a significantly greater tendency to choose sugammadex over neostigmine (P < 0.001). Conclusions: PtDAs intervention in preanesthesia consultations provided surgical patients clear knowledge and better support. PtDAs should also be made available in other medical fields to enhance shared clinical decision-making.
期刊Korean Journal of Anesthesiology
出版狀態已發佈 - 2022


  • anesthesia; neostigmine; sugammadex; shared decision-making; patient decision aids; decision conflicts