Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh; Deni Taleski; Brendan L. Wilkinson; Lakshmi C. Wijeyewickrem; Ty E. Adams; Robert N. Pike; Richard J. Payne

doi:10.1039/c1cc14773k

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrem, Ty E. Adams, Robert N. Pike, Richard J. Payne

研究成果: 雜誌貢獻 › 文章 › 同行評審

22 引文斯高帕斯（Scopus）

摘要

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

原文	英語
頁（從 - 到）	1547-1549
頁數	3
期刊	Chemical Communications
卷	48
發行號	10
DOIs	https://doi.org/10.1039/c1cc14773k
出版狀態	已發佈 - 1月 11 2012
對外發佈	是

ASJC Scopus subject areas

催化
電子、光磁材料
陶瓷和複合材料
一般化學
表面、塗料和薄膜
金屬和合金
材料化學

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10.1039/c1cc14773k

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abstract = "Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.",

author = "Hsieh, {Yves S.Y.} and Deni Taleski and Wilkinson, {Brendan L.} and Wijeyewickrem, {Lakshmi C.} and Adams, {Ty E.} and Pike, {Robert N.} and Payne, {Richard J.}",

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AU - Hsieh, Yves S.Y.

AU - Taleski, Deni

AU - Wilkinson, Brendan L.

AU - Wijeyewickrem, Lakshmi C.

AU - Adams, Ty E.

AU - Pike, Robert N.

AU - Payne, Richard J.

PY - 2012/1/11

Y1 - 2012/1/11

N2 - Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

AB - Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

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