Effect of glutaraldehyde on the humoral immunogenicity and structure of porcine dermal collagen membranes

King Jean Wu; Cheng Yi Wang; Hsein Kun Lu

doi:10.1016/j.archoralbio.2003.10.002

Effect of glutaraldehyde on the humoral immunogenicity and structure of porcine dermal collagen membranes

King Jean Wu, Cheng Yi Wang, Hsein Kun Lu

研究成果: 雜誌貢獻 › 文章 › 同行評審

18 引文斯高帕斯（Scopus）

摘要

Objectives: Our previous studies showed that the biodegradation rate of cross-linked porcine dermal collagen membrane (PDCM) could be retarded without changing its biocompatible character. The purpose of this study was to assay the humoral immune response of PDCM reconstitute with glutaraldehyde (GA) and observe their surface architectures. Methods: PDCM reconstituted with GA (0, 0.01, 0.05, and 3%) was implanted in 30 Sprague-Dawley rats. Sample sera were collected 3, 6, and 9 weeks after surgery and assayed with ELISA. The architectures of PDCMs were observed under SEM (100×). Results: The study showed that non cross-linked PDCM induced the highest immune response than any other cross-linked PDCMs (by optical density (OD) values, P

原文	英語
頁（從 - 到）	305-311
頁數	7
期刊	Archives of Oral Biology
卷	49
發行號	4
DOIs	https://doi.org/10.1016/j.archoralbio.2003.10.002
出版狀態	已發佈 - 4月 2004

ASJC Scopus subject areas

一般牙醫學
細胞生物學
耳鼻咽喉科

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10.1016/j.archoralbio.2003.10.002

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AU - Wang, Cheng Yi

AU - Lu, Hsein Kun

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KW - Glutaraldehyde crosslinking

KW - Immunogenicity

KW - PDCM

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Effect of glutaraldehyde on the humoral immunogenicity and structure of porcine dermal collagen membranes

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