TY - JOUR
T1 - Early bone response to machined, sandblasting acid etching (SLA) and novel surface-functionalization (SLAffinity) titanium implants
T2 - Characterization, biomechanical analysis and histological evaluation in pigs
AU - Chiang, Hsi Jen
AU - Hsu, Heng Jui
AU - Peng, Pei Wen
AU - Wu, Ching Zong
AU - Ou, Keng Liang
AU - Cheng, Han Yi
AU - Walinski, Christopher J.
AU - Sugiatno, Erwan
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The purpose of the present study was to examine early tissue response and osseointegration in the animal model. The surface morphologies of SLAffinity were characterized using scanning electron microscopy and atomic force microscopy. The microstructures were examined by X-ray diffraction, and hardness was measured by nanoindentation. Moreover, the safety and toxicity properties were evaluated using computer-aided programs and cell cytotoxicity assays. In the animal model, implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received three implants: machine, sandblasted, large grit, acid-etched, and SLAffinity-treated implants. The results showed that surface treatment did affect bone-to-implant contact (BIC) significantly. At 3 weeks, the SLAffinity-treated implants were found to present significantly higher BIC values than the untreated implants. The SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone tissue healing. As described above, the results of the present study demonstrate that the SLAffinity treatment is a reliable surface modification method.
AB - The purpose of the present study was to examine early tissue response and osseointegration in the animal model. The surface morphologies of SLAffinity were characterized using scanning electron microscopy and atomic force microscopy. The microstructures were examined by X-ray diffraction, and hardness was measured by nanoindentation. Moreover, the safety and toxicity properties were evaluated using computer-aided programs and cell cytotoxicity assays. In the animal model, implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received three implants: machine, sandblasted, large grit, acid-etched, and SLAffinity-treated implants. The results showed that surface treatment did affect bone-to-implant contact (BIC) significantly. At 3 weeks, the SLAffinity-treated implants were found to present significantly higher BIC values than the untreated implants. The SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone tissue healing. As described above, the results of the present study demonstrate that the SLAffinity treatment is a reliable surface modification method.
KW - dental implant
KW - early tissue response
KW - nano/microporous surface treatment
KW - osseointegration
UR - http://www.scopus.com/inward/record.url?scp=84955200910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955200910&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.35577
DO - 10.1002/jbm.a.35577
M3 - Article
C2 - 26418567
AN - SCOPUS:84955200910
SN - 1552-4973
VL - 104
SP - 397
EP - 405
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
IS - 2
ER -