TY - JOUR
T1 - Duration of red blood cell storage and inflammatory marker generation
AU - Sut, Caroline
AU - Tariket, Sofiane
AU - Chou, Ming Li
AU - Garraud, Olivier
AU - Laradi, Sandrine
AU - Hamzeh-Cognasse, Hind
AU - Seghatchian, Jerard
AU - Burnouf, Thierry
AU - Cognasse, Fabrice
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.
AB - Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.
KW - Inflammation
KW - Red blood cell
KW - Storage
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U2 - 10.2450/2017.0343-16
DO - 10.2450/2017.0343-16
M3 - Review article
C2 - 28263172
AN - SCOPUS:85015043507
SN - 1723-2007
VL - 15
SP - 145
EP - 152
JO - Blood Transfusion
JF - Blood Transfusion
IS - 2
ER -