Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects

Hao Jui Weng, Quoc Thao Trang Pham, Chia Wei Chang, Tsen Fang Tsai

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Pain and itch are both important manifestations of various disorders, such as herpes zoster, atopic dermatitis, and psoriasis. Growing evidence suggests that both sensations have shared mediators, overlapping neural circuitry, and similarities in sensitization processes. In fact, pain and itch coexist in some disorders. Determining pharmaceutical agents and targets for treating pain and itch concurrently is of scientific and clinical relevance. Here we review the neurobiology of pain and itch and discuss the pharmaceutical targets as well as novel compounds effective for the concurrent treatment of these sensations.
原文英語
文章編號892
期刊Pharmaceuticals
15
發行號7
DOIs
出版狀態已發佈 - 7月 2022

ASJC Scopus subject areas

  • 分子醫學
  • 藥學科學
  • 藥物發現

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