TY - JOUR
T1 - Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma
AU - Shih, Ying Yih
AU - Hsiao, Liang Tsai
AU - Yang, Ching Fen
AU - Wu, Yu Chung
AU - Chiou, Tzeon Jye
PY - 2008/1
Y1 - 2008/1
N2 - Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia. However, the relationship between IMF and malignant thymoma has not been published before. Here, we report a 48-year-old woman who was initially diagnosed of IMF with severe anemia and transfusion dependent. Five years later, malignant thymoma was found when she was examined for chronic cough. After performing extended thymectomy, her anemia dramatically recovered to normal and sustained for 2 years till last follow-up. Her splenomegaly and myelofibrosis were also improved. We hypothesized that her malignant thymoma induced the progression of IMF, especially in anemia.
AB - Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia. However, the relationship between IMF and malignant thymoma has not been published before. Here, we report a 48-year-old woman who was initially diagnosed of IMF with severe anemia and transfusion dependent. Five years later, malignant thymoma was found when she was examined for chronic cough. After performing extended thymectomy, her anemia dramatically recovered to normal and sustained for 2 years till last follow-up. Her splenomegaly and myelofibrosis were also improved. We hypothesized that her malignant thymoma induced the progression of IMF, especially in anemia.
KW - Anemia
KW - Danazol
KW - Idiopathic myelofibrosis
KW - Thymectomy
KW - Thymoma
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U2 - 10.1007/s12185-007-0012-0
DO - 10.1007/s12185-007-0012-0
M3 - Article
C2 - 18224414
AN - SCOPUS:41849122725
SN - 0925-5710
VL - 87
SP - 56
EP - 59
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 1
ER -