Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Chung Ping Liao; Edem Tchegnon; Lu Q. Le

doi:10.1016/j.jid.2018.08.008

Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Chung Ping Liao
, Edem Tchegnon
, Lu Q. Le

研究成果: 雜誌貢獻 › 評論/辯論 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

原文	英語
頁（從 - 到）	17-19
頁數	3
期刊	Journal of Investigative Dermatology
卷	139
發行號	1
DOIs	https://doi.org/10.1016/j.jid.2018.08.008
出版狀態	已發佈 - 1月 2019

ASJC Scopus subject areas

生物化學
分子生物學
皮膚科
細胞生物學

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10.1016/j.jid.2018.08.008

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Link to publication in Scopus

引用此

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title = "Double-Stranded RNA Sensing Determines Epithelial Cell Identity",

abstract = "Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.",

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AB - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

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Double-Stranded RNA Sensing Determines Epithelial Cell Identity

摘要

ASJC Scopus subject areas

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