TY - JOUR
T1 - Double-Stranded RNA Sensing Determines Epithelial Cell Identity
AU - Liao, Chung Ping
AU - Tchegnon, Edem
AU - Le, Lu Q.
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2019/1
Y1 - 2019/1
N2 - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.
AB - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.
UR - http://www.scopus.com/inward/record.url?scp=85056739688&partnerID=8YFLogxK
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U2 - 10.1016/j.jid.2018.08.008
DO - 10.1016/j.jid.2018.08.008
M3 - Comment/debate
C2 - 30579424
AN - SCOPUS:85056739688
SN - 0022-202X
VL - 139
SP - 17
EP - 19
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -