Dosimetric and efficiency comparison of high-dose radiotherapy for esophageal cancer: Volumetric modulated arc therapy versus fixed-field intensity-modulated radiotherapy

C. Y. Lin, W. Y. Huang, Y. M. Jen, C. M. Chen, Y. F. Su, H. L. Chao, C. S. Lin

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24 引文 斯高帕斯(Scopus)

摘要

Summary: The aim of this study was to compare high-dose volumetric modulated arc therapy (VMAT) and fixed-field intensity-modulated radiotherapy (ff-IMRT) plans for the treatment of patients with middle-thoracic esophageal cancer. Eight patients with cT2-3N0M0 middle-thoracic esophageal cancer were enrolled. The treatment planning system was the version 9 of the Pinnacle3 with SmartArc (Philips Healthcare, Fitchburg, WI, USA). VMAT and ff-IMRT treatment plans were generated for each case, and both techniques were used to deliver 50Gy to the planning target volume (PTV50) and then provided a 16-Gy boost (PTV66). The VMAT plans provided superior PTV66 coverage compared with the ff-IMRT plans (P = 0.034), whereas the ff-IMRT plans provided more appropriate dose homogeneity to the PTV50 (P = 0.017). In the lung, the V5 and V10 were lower for the ff-IMRT plans than for the VMAT plans, whereas the V20 was lower for the VMAT plans. The delivery time was significantly shorter for the VMAT plans than for the ff-IMRT plans (P = 0.012). In addition, the VMAT plans delivered fewer monitor units. The VMAT technique required a shorter planning time than the ff-IMRT technique (3.8 ± 0.8 hours vs. 5.4 ± 0.6 hours, P = 0.011). The major advantages of VMAT plans are higher efficiency and an approximately 50% reduction in delivery time compared with the ff-IMRT plans, with comparable plan quality. Further clinical investigations to evaluate the use of high-dose VMAT for the treatment of esophageal cancer are warranted.
原文英語
頁(從 - 到)585-590
頁數6
期刊Diseases of the Esophagus
27
發行號6
DOIs
出版狀態已發佈 - 8月 2014
對外發佈

ASJC Scopus subject areas

  • 一般醫學

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