摘要
The DNA methylation program of the fruit fly Drosophila melanogaster is carried out by the single DNA methyltransferase gene dDnmt2, the function of which is unknown before. We present evidence that intactness of the gene is required for maintenance of the normal life span of the fruit flies. In contrast, overexpression of dDnmt2 could extend Drosophila life span. The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general.
原文 | 英語 |
---|---|
頁(從 - 到) | 861-864 |
頁數 | 4 |
期刊 | Journal of Biological Chemistry |
卷 | 280 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 1月 14 2005 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學
- 分子生物學
- 細胞生物學