摘要
Guanine (G)-rich DNA sequences can adopt stable G-quadruplex structures by G-tetrad hydrogen-bonding and hydrophobic stacking. Recently, it has been shown that a DNA sequence forms an aptamer (termed 93del) and adopts a novel dimeric quadruplex folding topology in K+ solution. This aptamer exhibits anti-HIV1 integrase activity in the nanomolar range in vitro. A docking-based model of the 93del-integrase complex positions the DNA aptamer within a channel of the tetrameric integrase. This mutual fitting blocks several catalytic amino acid residues that are essential for integrase function, and accounts for the anti-HIV1 activity of the 93del aptamer.
原文 | 英語 |
---|---|
頁(從 - 到) | 231-234 |
頁數 | 4 |
期刊 | Trends in Biochemical Sciences |
卷 | 30 |
發行號 | 5 |
DOIs | |
出版狀態 | 已發佈 - 5月 2005 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學
- 分子生物學