Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block: Role of Setting of Ventricular Pacing

Chun An Chen, Jou Kou Wang, Ming Tai Lin, Chun Wei Lu, Kun Lang Wu, Shuenn Nan Chiu, Hsin Hui Chiu, En Ting Wu, Hung Chi Lue, Mei Hwan Wu

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients <18 years of age at diagnosis were enrolled. Twenty-eight (80%) received pacemakers after a mean follow-up of 10 years, and most were paced from right ventricular (RV) apex (n = 23). None of the 7 patients without pacemakers developed DCM, whereas 8 (35%) paced from RV apex had DCM 2.6 ± 2.2 years after pacing. The percentage of ventricular pacing was >90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.

原文英語
頁(從 - 到)681-688
頁數8
期刊Journal of Cardiac Failure
15
發行號8
DOIs
出版狀態已發佈 - 10月 2009
對外發佈

ASJC Scopus subject areas

  • 心臟病學與心血管醫學

指紋

深入研究「Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block: Role of Setting of Ventricular Pacing」主題。共同形成了獨特的指紋。

引用此