TY - JOUR
T1 - Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block
T2 - Role of Setting of Ventricular Pacing
AU - Chen, Chun An
AU - Wang, Jou Kou
AU - Lin, Ming Tai
AU - Lu, Chun Wei
AU - Wu, Kun Lang
AU - Chiu, Shuenn Nan
AU - Chiu, Hsin Hui
AU - Wu, En Ting
AU - Lue, Hung Chi
AU - Wu, Mei Hwan
PY - 2009/10
Y1 - 2009/10
N2 - Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.
AB - Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.
KW - Complete atrioventricular block
KW - dilated cardiomyopathy
KW - pacemakers
KW - right ventricular apical pacing
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U2 - 10.1016/j.cardfail.2009.04.002
DO - 10.1016/j.cardfail.2009.04.002
M3 - Article
C2 - 19786257
AN - SCOPUS:70349312638
SN - 1071-9164
VL - 15
SP - 681
EP - 688
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 8
ER -