TY - JOUR
T1 - Die sensomotorische Domäne im Research-Domain-Criteria-System
T2 - Fortschritte und Perspektiven
AU - Hirjak, Dusan
AU - Fritze, Stefan
AU - Northoff, Georg
AU - Kubera, Katharina M.
AU - Wolf, Robert Christian
N1 - Publisher Copyright:
© 2021, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
PY - 2021
Y1 - 2021
N2 - Over the past three decades research interest in hypokinetic, hyperkinetic, sensorimotor and psychomotor abnormalities in mental disorders has steadily increased. This development has led to an increasing number of scientific initiatives that have not only highlighted the clinical need for early detection of extrapyramidal motor symptoms, tardive dyskinesia and catatonia but also provided numerous neurobiological findings and clinically relevant results based on the pathology of the sensorimotor system in patients with mental disorders. In view of these developments in January 2019 the National Institute of Mental Health (NIMH) research domain criteria (RDoC) initiative introduced a sixth domain called the sensorimotor domain to address deficits in the sensorimotor system and associated behavioral abnormalities. To draw attention to the rapid progress just since the introduction of the sensorimotor domain, a 2-year (1 January 2019–18 February 2021) systematic review is presented highlighting recent neuroimaging findings and discussing challenges for future research. In summary, aberrant sensorimotor processing in mental disorders is associated with dysfunction of the cerebello-thalamo-motor cortex network, which interacts with (social)cognitive and affective systems. Initial longitudinal and interventional studies highlight the translational potential of the sensorimotor domain.
AB - Over the past three decades research interest in hypokinetic, hyperkinetic, sensorimotor and psychomotor abnormalities in mental disorders has steadily increased. This development has led to an increasing number of scientific initiatives that have not only highlighted the clinical need for early detection of extrapyramidal motor symptoms, tardive dyskinesia and catatonia but also provided numerous neurobiological findings and clinically relevant results based on the pathology of the sensorimotor system in patients with mental disorders. In view of these developments in January 2019 the National Institute of Mental Health (NIMH) research domain criteria (RDoC) initiative introduced a sixth domain called the sensorimotor domain to address deficits in the sensorimotor system and associated behavioral abnormalities. To draw attention to the rapid progress just since the introduction of the sensorimotor domain, a 2-year (1 January 2019–18 February 2021) systematic review is presented highlighting recent neuroimaging findings and discussing challenges for future research. In summary, aberrant sensorimotor processing in mental disorders is associated with dysfunction of the cerebello-thalamo-motor cortex network, which interacts with (social)cognitive and affective systems. Initial longitudinal and interventional studies highlight the translational potential of the sensorimotor domain.
KW - Magnetic resonance imaging
KW - Neuroimaging
KW - Psychiatric illnesses
KW - Psychomotor
KW - Sensorimotor dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85107796998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107796998&partnerID=8YFLogxK
U2 - 10.1007/s00115-021-01144-7
DO - 10.1007/s00115-021-01144-7
M3 - 文献综述
C2 - 34115150
AN - SCOPUS:85107796998
SN - 0028-2804
VL - 92
SP - 915
EP - 924
JO - Nervenarzt
JF - Nervenarzt
IS - 9
ER -