Five cases in a chronic myelogenous leukemia series were originally categorized as Ph1 positive and later developed another variant of the Ph1 chromosome. With the new Giemsa banding technique, it appeared to be a dicentric Ph1 chromosome. This chromosome was first noted 23 mth after diagnosis, with the latest appearance at 57 mth. Survival in 3 of the 5 patients after the appearance of the dicentric Ph1 chromosome was 6, 16, and 35 mth; the other 2 are still alive.
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