Development of N,O-(carboxymethyl)chitosan/collagen matrixes as a wound dressing

Ray Neng Chen, Gen Ming Wang, Chien Ho Chen, Hsiu O. Ho, Ming Thau Sheu

研究成果: 雜誌貢獻文章同行評審

184 引文 斯高帕斯(Scopus)


In an attempt to accelerate wound healing by stimulating the recruitment of fibroblasts and improve the mechanical properties of collagen matrixes, N,O-(carboxymethyl)chitosan (NOCC) was incorporated into the backbone of a collagen (COL) matrix without or with chondroitin sulfate (CS) or an acellular dermal matrix (ADM). The result of a cell migration study demonstrated that the migration of fibroblasts was significantly enhanced by NOCC in a concentration-dependent manner. In the analysis with a dynamic mechanical analyzer, NOCC/CS/COL matrixes presented higher tensile strengths than did NOCC/ADM/COL matrixes. Skin fibroblasts cultured on the matrixes containing NOCC showed increased proliferation and secretion of three kinds of cytokines compared with the control. Results of the in vivo wound healing study showed that matrixes incorporating NOCC showed markedly enhanced wound healing compared with the control. Therefore, the above results clearly suggest that NOCC/COL matrixes containing CS or ADM can be potential wound dressings for clinical applications.
頁(從 - 到)1058-1064
出版狀態已發佈 - 4月 2006

ASJC Scopus subject areas

  • 生物工程
  • 材料化學
  • 聚合物和塑料
  • 生物材料


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