摘要
Point mutations of the K-ras gene have been reported in a wide variety of human tumors. By using polymerase chain reaction followed by direct DNA sequencing, we screened for point mutations at codons 12 and 13 of the K-ras gene in specimens obtained from fresh frozen tumors in 38 patients with non-small cell lung cancers. Point mutations were detected in two of 38 (5.3%) resected non-small cell lung cancers. Both of them were G to T transversions. One patient was found to have a K-ras codon 13 point mutation (GGC to TGC, gly to cys), while the other had a codon 12 point mutation (GGT to GTT, gly to val). Based on the limited numbers in this study, we found that the frequency of K-ras point mutations in codons 12 and 13 among Asian patients with lung adenocarcinomas was lower than that detected among Caucasian patients.
原文 | 英語 |
---|---|
頁(從 - 到) | 741-745 |
頁數 | 5 |
期刊 | Journal of the Formosan Medical Association = Taiwan yi zhi |
卷 | 95 |
發行號 | 10 |
出版狀態 | 已發佈 - 1996 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 醫藥 (全部)