Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones

Chia Chung Lee, Kuo Feng Huang, Deh Ming Chang, Jung Jung Hsu, Fong Chun Huang, Kai Ning Shih, Chun Liang Chen, Tsung Chih Chen, Ruei Huei Chen, Jing Jer Lin, Hsu Shan Huang

研究成果: 雜誌貢獻文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

A series of symmetrical disubstituded 1,8-diamidoanthraquinones were synthesized and evaluated for anti-proliferation, telomerase inhibitory by TRAP assay, and hTERT expression by SEAP assay. All of the compounds tested, except for compounds 3a and 3s were selected by the NCI screening system. In addition, compounds 4e and 4k exhibited inhibitory effects on telomerase activity. Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase targeting strategy.
原文英語
頁(從 - 到)102-112
頁數11
期刊European Journal of Medicinal Chemistry
50
DOIs
出版狀態已發佈 - 4月 2012
對外發佈

ASJC Scopus subject areas

  • 藥物發現
  • 有機化學
  • 藥理

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